![]() These differences may explain the discrepant results of studies of TAMs in the biologic regulation of cancers. All macrophages, including TAMs, show a high level of plasticity and variation in phenotype and activation state that are modified by the microenvironment. Further complicating targeting of TAMs is that specific subsets may alternatively facilitate or inhibit neoplastic transformation and metastasis. However, the lack of reliable and specific markers to identify and differentiate TAM subsets has limited the development of prognostic algorithms or development of targeted therapies. ![]() ![]() These play critical roles in the development, progression, and metastasis of breast cancer, and in future risk models could be included together with tumor size and nodal status to guide treatment decisions. One of the most studied immune cell populations is tumor-associated macrophages (TAMs). Breast cancers consist of complex cellular microenvironments where interactions between tumor cells, stroma, and immune cells influence cancer cell growth and response to treatment.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |